Pet Induces IL1, TNF , MIF and IL1Ra Through the IKK /NF B Pathway
نویسندگان
چکیده
Plasmid encoded protein (Pet), a product of E. coli, infiltrates leukocyte in experimental models and acts on macrophages as a chemokine. As an immune response orchestrator, macrophages play an important role in inducing proinflammatory cytokines. In this work, we tested whether in macrophages Pet stimulates the expression of IL1, TNF , MIF and the antagonist IL1Ra. We also sought the IKK /NF B pathway as a possible mediator. We found that indeed Pet increases the mRNA of inflammatory cytokines and the antagonist IL1Ra with different rates and kinetics through the IKK /NF B pathway, which could be consistent as a factor in chronic inflammation.
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